Archives: Projects

Novel bioink carrier formulations for 3D bioprinting of skeletal muscle

Theme 2: Advanced materials and manufacturing Prof. Peter Currie Prof. Laurence Meagher The 3D bioprinting of cells is a recent area of research that can create complex, cell seeded scaffolds with defined 3D shape, geometry and more tissue-like properties. It holds great promise for advanced tissue engineering and drug screening. A key advantages is the …

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In vivo Antimicrobial Efficacy of Novel Bactericidal Surfaces for Use in Intramedullary Implants

Theme 3: Tissue engineering Prof. Dietmar W Hutmacher Dr. Laura Bray Dr. Siamek Saifzadeh Dr. Roland Steck This project will investigate the in vivo efficacy of two technologies using emitting metal ions and bactericidal nanostructures. While the mechanisms of antimicrobial efficacy are expected to be substantially different, both technologies have shown bactericidal properties under in …

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Novel hydrogel materials for the culture of patient-derived cells and tissues

Theme 3: Tissue engineering Dr. Laura Bray Dr. Mark Adams The overarching objective of this project is to validate a novel hydrogel system as a physiologically relevant model for the maintenance and propagation of human patient-derived primary cells and tissues. It is hypothesised that the hydrogels will allow for the extended culture of breast, bladder …

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Improving efficacy of CAR T cell therapies for solid tumors

Theme 3: Tissue engineering Prof. Gail Risbridger The MURAL cohort of patient prostate cancer xenografts is a world class pre-clinical platform for drug discovery and testing. It is particularly suited to evaluating combination therapies since the scale and scope of preclinical studies is far greater than that which can be assessed in individual patients. This …

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Implantable devices for vaccine delivery

Theme 2: Advanced materials and manufacturing A/Prof. Tim Dargaville Dr. Mark Adams Prof. Laurence Meagher The aim of this project is to investigate polymer devices for vaccine delivery. Specially, the project will focus on degradable polymer tubes for delayed, bolus delivery of vaccines including tetanus toxoid and other vaccines and drugs relevant to wildlife, cattle …

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High-throughput 3D bioprinting of the tumour microenvironment

Theme 3: Tissue engineering Dr. Laura Bray A/Prof. Yi-Chin Toh Prof. Gail Risbridger This project aims to develop methods and materials to facilitate the high-throughput 3D printing of complex tumour microenvironments with defined mechanical and biochemical properties incorporating cancer, stromal, and endothelial cells, as well as tissue- and pathology-specific extracellular matrix components. The system will …

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Development of a novel biodegradable scaffold for the repair of injured or degenerate cartilaginous tissues including the intervertebral disc

Theme 2: Advanced materials and manufacturing A/Prof. Jessica Frith Cartilage tissue possesses a limited regenerative potential and degeneration of the cartilage is a common problem following injury or with aging. This includes degeneration of the cartilaginous tissue of the intervertebral disc, which is a leading cause of lower back pain. Current therapies cannot restore the …

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