Theme 3: Tissue Engineering Prof. Neil Cameron Peripheral nerve injury (PNI) often leaves life-long disabilities. In the US, the typical annual number of nerve repair procedures exceeds 500,000 and this is projected to increase over time. Nerve autografts are the current gold standard treatment, but these often lead to donor site morbidity, nerve mismatch and …
Theme 2: Advanced materials and manufacturing Prof. Peter Currie Prof. Laurence Meagher The 3D bioprinting of cells is a recent area of research that can create complex, cell seeded scaffolds with defined 3D shape, geometry and more tissue-like properties. It holds great promise for advanced tissue engineering and drug screening. A key advantages is the …
Novel bioink carrier formulations for 3D bioprinting of skeletal muscle Read More »
Theme 1: Engineering process efficiencies Prof. Nicolas Voelcker Dr. Roey Elnathan Re-engineering patients’ immune cells to treat their cancers is a rapidly growing field in cancer treatment. One of the world’s newest forms of cancer immunotherapies, CAR-T cell therapy, has generated enormous global excitement due to promising results in treating some blood cancers. The joint …
Theme 3: Tissue engineering Prof. Dietmar W Hutmacher Dr. Laura Bray Dr. Siamek Saifzadeh Dr. Roland Steck This project will investigate the in vivo efficacy of two technologies using emitting metal ions and bactericidal nanostructures. While the mechanisms of antimicrobial efficacy are expected to be substantially different, both technologies have shown bactericidal properties under in …
Theme 3: Tissue engineering Dr. Laura Bray Dr. Mark Adams The overarching objective of this project is to validate a novel hydrogel system as a physiologically relevant model for the maintenance and propagation of human patient-derived primary cells and tissues. It is hypothesised that the hydrogels will allow for the extended culture of breast, bladder …
Novel hydrogel materials for the culture of patient-derived cells and tissues Read More »
Theme 3: Tissue engineering Prof. John Bertram Prof. Jose Polo Dr. Bo Sun Podocytes are the cells in kidney glomeruli responsible for blood filtration. Loss and alteration of podocytes lead to dysfunction of the glomerular filtration barrier which can result in Chronic Kidney Disease (CKD). CKD is estimated to affect 11-13% of the world …
Reprograming of different cell types into podocytes Read More »
Theme 3: Tissue engineering Prof. Gail Risbridger The MURAL cohort of patient prostate cancer xenografts is a world class pre-clinical platform for drug discovery and testing. It is particularly suited to evaluating combination therapies since the scale and scope of preclinical studies is far greater than that which can be assessed in individual patients. This …
Improving efficacy of CAR T cell therapies for solid tumors Read More »
Theme 2: Advanced materials and manufacturing A/Prof. Tim Dargaville Dr. Mark Adams Prof. Laurence Meagher The aim of this project is to investigate polymer devices for vaccine delivery. Specially, the project will focus on degradable polymer tubes for delayed, bolus delivery of vaccines including tetanus toxoid and other vaccines and drugs relevant to wildlife, cattle …
Theme 3: Tissue engineering Dr. Laura Bray A/Prof. Yi-Chin Toh Prof. Gail Risbridger This project aims to develop methods and materials to facilitate the high-throughput 3D printing of complex tumour microenvironments with defined mechanical and biochemical properties incorporating cancer, stromal, and endothelial cells, as well as tissue- and pathology-specific extracellular matrix components. The system will …
High-throughput 3D bioprinting of the tumour microenvironment Read More »
Theme 3: Tissue engineering Dr. Laura Bray A/Prof. Larisa Haupt Prof. Nathan Subramaniam, Prof. Gail Risbridger This project will validate the 3D in vitro starPEG-heparin hydrogel model as a physiologically relevant model that can screen for antineoplastic breast cancer therapeutics. It is hypothesized that the 3D in vitro model is physiologically precise enough as a …
ARC CTET Training Centre for Cell & Tissue Engineering Technologies received funding from the Australian Government through the Australian Research Council.
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